Researcher - Developmental Neurobiology (Han Lab)

Humans have the largest neocortex relative to their brain size, and its folded surface is thought to be the root of our unique mental abilities. What cellular and molecular mechanisms drive the development and evolution of this remarkable structure? How do disruptions in these mechanisms lead to neurodevelopmental disorders and brain tumors? We aim to answer these fundamental questions by investigating the neural progenitor cells that construct the brain during development.

To uncover the mechanisms regulating human neural progenitor cells, we developed the first stable and robust genetic mouse model, in which neural progenitors acquire the key features of human neural progenitors, driving the transformation of the small, smooth mouse cortex into an expanded, folded cortex. In addition to this unique and powerful animal model, we employ a broad range of approaches, including human pluripotent stem cells, brain organoids, genome editing, high-resolution imaging, single-cell sequencing, spatial transcriptomics, and proteomics. Please refer to our website (https://www.stjude.org/research/labs/han-lab.html) for further information.

The immediate research project will focus on characterizing novel cellular models of a pediatric brain tumor, which have been derived from patient samples and human pluripotent stem cells. The successful candidate will work in a highly collaborative environment to investigate the mechanisms that drive tumorigenesis and to develop therapeutic approaches that target those mechanisms.

The ideal candidate will be self-motivated, organized, and enthusiastic about biomedical research. Experience in stem cells, organoid models, molecular biology, and related methodologies is desirable. Candidates with a strong desire to learn new techniques and to contribute to a collaborative research to tackle pediatric brain tumors are encouraged to apply.

To apply, please send a summary of previous research, curriculum vitae, and contact information for references to young-goo.han@stjude.org.

Job Responsibilities:

• Performs laboratory experiments as directed using specific and prescribed techniques/protocols.
• Follows basic protocols, implementing experimental techniques prescribed by supervisor and providing basic troubleshooting where appropriate.
• Accurately records experimental procedures and data.
• May draft results/data for posters, presentations or publications
• Operates lab equipment.
• Performs other related duties as assigned in order to meet the goals of the department and institution
• Maintains regular and predictable attendance

Minimum Education and/or Training:

• Bachelor's degree in relevant scientific area is required

Minimum Experience:

• no experience required

Compensation

Explore our exceptional benefits!

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